EXPLORATION OF GERMLINE CORRELATES AND RISK OF IMMUNE-RELATED ADVERSE EVENTS IN ADVANCED CANCER PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS

Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors

Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can Magnifiers be observed in select populations.However, patients may exhibit significant immune-related adverse events (irAEs) that may lead to morbidity.There is limited information on whether the presence of specific germline mu

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Untargeted Metabolomics Analysis Reveals Toxicity Based on the Sex and Sexual Maturity of Single Low-Dose DEHP Exposure

Di-(2-Ethylhexyl) phthalate (DEHP) is a prevalent environmental endocrine disruptor that affects homeostasis, reproduction, and developmental processes.The effects of DEHP have been shown to differ based on sex and sexual maturity.This study examines the metabolic profiles of mature adult rats from both sexes, aged 10 weeks, and adolescent female r

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